Environment sensitive fluorescent analogue of biologically active oxazoles differentially recognizes human serum albumin and bovine serum albumin: Photophysical and molecular modeling studies

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• 作者：Jyotirmay Maiti^a ; Suman Biswas^a ; Ankur Chaudhuri^b ; Sandipan Chakraborty^c ; ¹ ; Sibani Chakraborty^b ; Ranjan Das^a ; ^{ranjan.das68@gmail.com}
• 关键词：Fluorophore ; Association constant ; Steric complementarity ; Van der Waals interactions ; Electrostatic interactions
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：175
• 期：Complete
• 页码：191-199
• 全文大小：1434 K
• 卷排序：175

文摘

The steady state emission spectra of DMOBA in BSA is different from HSA The dye-protein binding interactions are remarkably stronger for BSA than HSA Binding to BSA is dictated by the van der Waals and hydrogen bonding interactions, whereas, for HSA it is guided by polar interactions DMOBA is located respectively, in Sudlow’s site II and Sudlow’s site I of BSA and HSA.