Glucocorticoid receptor mediated the propofol self-administration by dopamine D1 receptor in nucleus accumbens
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- 作者：Binbin Wu ; Yuyuan Liang ; Zhanglei Dong ; Zhichuan Chen ; Gaolong Zhang ; Wenxuan Lin ; Sicong Wang ; Benfu Wang ; Ren-Shan Ge ; raygee0828@163.com" class="auth_mail" title="E-mail the corresponding author ; Qingquan Lian ; lianqingquanmz@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; D1 receptor ; dopamine D1 receptor ; D2 receptor ; dopamine D2 receptor ; ELISA ; enzyme-linked immunosorbent assay ; FR1 ; fixed ratio 1 ; GC ; glucocorticoids ; GR ; glucocorticoid receptors ; HPA ; hypothalamic&ndash ; pituitary&ndash ; adrenal axis ; MR ; mineralocorticoid receptor ; NAc ; nucleus accumbens ; VTA ; ventral tegmental area
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：22 July 2016
- 年：2016
- 卷：328
- 期：Complete
- 页码：184-193
- 全文大小：1369 K
文摘
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Dexamethasone reduces plasma corticosterone levels.
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Dexamethasone down-regulates the expression of D1 receptor in the NAc.
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RU486 down-regulates the expression of D1 receptor in the NAc.
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GR not MR blockade reverses propofol addiction.