SHORT TERM FLUVASTATIN TREATMENT LOWERS SERUM ASYMMETRIC DIMETHYLARGININE LEVELS IN PATIENTS WITH METABOLIC SYNDROME
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文摘
We applied a genome-wide high-density single-nucleotide-polymorphism (SNP) genotyping approach to a cohort of samples with and without ischaemic stroke (n=278 and 275, respectively), and did an association analysis adjusted for known confounders in a final cohort of 249 cases and 268 controls. More than 400 000 unique SNPs were assayed.

Findings

We produced more than 200 million genotypes in 553 unique participants. The raw genotypes of all the controls have been posted publicly in a previous study of Parkinson's disease. From this effort, results of genotype and allele association tests have been publicly posted for 88 % of stroke patients who provided proper consent for public release. Preliminary analysis of these data did not reveal any single locus conferring a large effect on risk for ischaemic stroke.

Interpretation

The data generated here comprise the first phase of a genome-wide association analysis in patients with stroke. Release of phase I results generated in these publicly available samples from each consenting individual makes this dataset a valuable resource for data-mining and augmentation.


m/science?_ob=MImg&_imagekey=B6X3F-4ND70YF-1-8&_cdi=7297&_user=10&_orig=article&_coverDate=05 % 2F31 % 2F2007&_sk=999939994&view=c&wchp=dGLbVzz-zSkWz&md5=474828c56b529b131258a9a1b06b13f4&ie=/sdarticle.pdf"">mg name=""pdf"" style=""vertical-align:absmiddle;"" border=""0"" src=""http://www.sciencedirect.com/scidirimg/icon_pdf.gif"" alt=""""> Purchase PDF (165 K)
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mg src=""/scidirimg/bullet_square.gif"" alt="""">mt=high&_coverDate=06 % 2F15 % 2F2007&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f48b2019a5c5967d453e50ccbcf3b34a"" onMouseOver=""InfoBubble.show('infobubble_2','mlktLink_2')"" onMouseOut=""InfoBubble.timeout()"">Search of type 2 diabetes susceptibility gene on chromo...
Biochemical and Biophysical Research Communications
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mg border=0 src=""/scidirimg/jrn_nsub.gif"" alt=""You are not entitled to access the full text of this document"" title=""You are not entitled to access the full text of this document"" width=12 height=14""> m/science?_ob=ArticleURL&_udi=B6WBK-4NHVCSF-J&_user=10&_coverDate=06 % 2F15 % 2F2007&_rdoc=1&_fmt=high&_orig=article&_cdi=6713&_sort=v&_docanchor=&view=c&_ct=2&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=804c36872a321a346594e69e64acd7f7"">Search of type 2 diabetes susceptibility gene on chromosome 20q
Biochemical and Biophysical Research Communications, Volume 357, Issue 4, 15 June 2007, Pages 1100-1106
F. Takeuchi, K. Yanai, H. Inomata, N. Kuzuya, H. Kajio, S. Honjo, N. Takeda, Y. Kaburagi, K. Yasuda, S. Shirasawa, T. Sasazuki, N. Kato

Abstract
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Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad region on chromosome 20q, where the hepatocyte nuclear factor-4α (HNF4A) has been noted as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the relevant region, we examined the disease association by using 1145 SNPs in two-step screening in the Japanese population. The marker screening enabled us to identify significant disease association in the lipopolysaccharide binding protein (LBP) but not in the HNF4A locus. In a 17.7-Mb interval screened, the strongest association was identified for a SNP, rs2232592, located in the intron of LBP, with an estimated odds ratio of 1.73 (95 % CI 1.30–2.31) (P = 0.0002) in the whole study panel involving 675 case and 474 control subjects. Our data suggest that the LBP gene may confer genetic susceptibility to T2D and this warrants further replication study.

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