Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model
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- 作者：Prativa Sherchana ; Lei Huanga ; b ; Yuechun Wanga ; Onat Akyola ; Jiping Tanga ; John H. Zhanga ; b ; c ; johnzhang3910@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SBI ; surgical brain injury ; Robo1 ; roundabout1 ; CD45 ; cluster of differentiation 45 ; MPO ; myeloperoxidase ; srGAP1 ; Slit-Robo GTPase activating protein 1 ; ELISA ; enzyme linked immunosorbent assay ; ICV ; intracerebroventricular ; PBS ; phosphate buffered saline ; NeuN ; neuronal nuclei ; GFAP ; glial fibrillary acidic protein ; PAK ; p21 activated kinase ; PBD ; p21 binding domain
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：164-173
- 全文大小：1782 K
文摘
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Peripheral immune cell infiltration increased at the perisurgical site after SBI.
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Endogenous Slit2 was increased as a protective mechanism after SBI.
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Recombinant Slit2 attenuated brain edema by reducing neuroinflammation.
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Recombinant Slit2 reduced neuroinflammation by decreasing immune cell infiltration.
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Recombinant Slit2 inhibited immune cell migration dependent on Robo1-SrGAP1 pathway.