Peripheral immune cell infiltration increased at the perisurgical site after SBI.
Endogenous Slit2 was increased as a protective mechanism after SBI.
Recombinant Slit2 attenuated brain edema by reducing neuroinflammation.
Recombinant Slit2 reduced neuroinflammation by decreasing immune cell infiltration.
Recombinant Slit2 inhibited immune cell migration dependent on Robo1-SrGAP1 pathway.