Photo-enhancement of macrophage phagocytic activity via Rac1-mediated signaling pathway: Implications for bacterial infection
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- 作者：Cuixia Lu1 ; Zhijin Fan1 ; Da Xing ; xingda@scnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CA ; constitutively activated ; CFP ; cyan fluorescent protein ; DN ; dominant negative ; FRET ; fluorescence resonance energy transfer ; FCS ; fetal calf serum ; FITC ; fluorescein isothiocyanate ; GEF ; guanine nucleiotde-exchange factor ; GST ; glutathione-S-transferase ; LPLI ; low-power laser irradiation ; NPF ; nucleation-promoting factor ; PAK ; p21-activated kinases ; PBD ; the Rac/Cdc42 (p21) binding domain ; PP1 ; 1-(1 ; 1-dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3 ; 4-d]pyrimidin ; PI3K ; phosphatidylinositol
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：206-216
- 全文大小：3678 K
文摘
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LPLI enhanced the phagocytic activity of macrophages.
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Rac1 is essential for LPLI-induced actin polymerization and phagocytosis.
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Photoactivation of Rac1 is dependent on the Src/PI3K/Vav1 pathway.
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LPLI-treated mice exhibite improved resistance to bacterial infection.