Core promoter-specific gene regulation: TATA box selectivity and Initiator-dependent bi-directionality of serum response factor-activated transcription
详细信息 查看全文
- 作者：Muyu Xua ; 1 ; Elsie Gonzalez-Hurtadoa ; b ; 2 ; Ernest Martineza ; b ; ernest.martinez@ucr.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gene regulation ; Core promoter-selective transcription activation ; RNA polymerase II ; TATA box ; TATA-binding protein
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1859
- 期：4
- 页码：553-563
- 全文大小：871 K
文摘
- •
The ACTB upstream activating sequence (UAS) only activates TATA-containing promoters.
- •
Serum response factor (SRF) and the TATA box-binding activity of TBP are important.
- •
An Initiator (INR) core element confers bi-directional activity to the UAS of ACTB.
- •
SRF regulates the cytoskeleton/contractile gene family via TATA-containing promoters.
- •
Gene-specific regulation involves matching regulatory and core promoter elements.