Complement MASP-1 enhances adhesion between endothelial cells and neutrophils by up-regulating E‐selectin expression
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- 作者：Pé ; ter K. Jania ; 1 ; Endre Schwanera ; 1 ; Erika Kajdá ; csia ; Má ; rta L. Debreczenia ; Rita Ungai-Salá ; nkib ; c ; d ; Jó ; zsef Dobó ; e ; Zoltá ; n Doleschallf ; Já ; nos Rigó ; Jr.g ; Mikló ; s Geiszth ; Bá ; lint Szabó ; c ; d ; Pé ; ter Gá ; le ; Lá ; szló ; Cervenaka ; cervenak.laszlo@med.semmelweis-univ.hu" class="auth_mail" title="E-mail the corresponding author ; cervenak.laszlo@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HUVEC ; human umbilical vein endothelial cell ; MBL ; mannan-binding lectin ; MASP ; mannan-binding lectin-associated serine protease ; PAR ; protease-activated receptor
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：38-47
- 全文大小：2157 K
文摘
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RMASP-1 down-regulated the expression of ICAM‐2 at mRNA and protein level.
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RMASP-1 up-regulated the mRNA expression of E-selectin and VCAM-1.
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RMASP-1 also up-regulated the expression of E-selectin at protein level.
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Adhesion of dPLB‐985 cells were stronger to rMASP‐1 treated HUVECs than to controls.