Sequence diversity and positive selection at the Duffy-binding protein genes of Plasmodium knowlesi and P. cynomolgi: Analysis of the complete coding sequences of Thai isolates
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- 作者：Chaturong Putaporntip ; p.chaturong@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Napaporn Kuamsab ; Somchai Jongwutiwes
- 关键词：Plasmodium knowlesi ; Plasmodium cynomolgi ; Duffy binding protein ; Sequence diversity ; Natural selection ; Macaque
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：367-375
- 全文大小：1441 K
文摘
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Nucleotide diversity of DBP is highly variable across malaria species.
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Positive selection occurred in domains I, II and IV of PvDBP, domain V of PcyDBP1 and the DARC binding site of PkDBPα.
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The DBP gene families have arisen following the model of concerted evolution.
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Duplication of the gene members of PkDBP postdated the divergence from the PcyDBP and PvDBP lineages.
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P. knowlesi from Thailand shared closely related domains II of PkDBPα and PkDBPγ with those from Peninsular Malaysia.