Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin
详细信息 查看全文
- 作者：Masataka Murahashia ; Siro Simizua ; Masahiko Moriokaa ; Kazuo Umezawab ; umezawa@aichi-med-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：15-Deoxyspergualin ; Biotin conjugate ; Target protein ; Poly(rC) binding protein 2 (PCBP2) ; Signal transducer and activator of transcription (STAT)
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：445-449
- 全文大小：1026 K
文摘
- 10">
- •
10">Fifteen-deoxyspergualin (DSG) is an immunosuppressive agent clinically used.
- •
10a">We have identified PCBP2, an RNA-binding protein, as a molecular target of DSG.
- •
10b">Alteration of PCBP2 activity may explain the immunosuppressive activity of DSG.