Trinucleotide repeat expansion of TATA-binding protein gene associated with Parkinson's disease: A Thai multicenter study
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- 作者：Lulin Choubtuma ; b ; Pirada Witoonpanicha ; Kongkiat Kulkantrakornc ; Suchat Hanchaiphiboolkuld ; Sunsanee Pongpakdeee ; Somsak Tiamkaof ; Teeratorn Pulkesa ; teeratorn.pul@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：Spinocerebellar ataxia type 17 ; TATA box-binding protein gene ; TBP ; Trinucleotide repeat expansion ; Parkinson's disease
- 刊名：Parkinsonism & Related Disorders
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：28
- 期：Complete
- 页码：146-149
- 全文大小：204 K
文摘
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This is the first study on SCA17 mutations in association with Parkinson disease (PD) in Thais.
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The study shows that SCA17 low-range expansions (41–45 repeats) may be risk of developing PD.
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Aging may be an important factor for disease expression related to SCA17 low-range expansions.