Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23/IL-23R/β-catenin pathway
详细信息 查看全文
- 作者：Bing Tua ; 1 ; Shen Liua ; 1 ; Guangwang Liub ; Wei Yanc ; Yugang Wangd ; Zhiwei Lia ; Cunyi Fana ; fancunyi888@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Macrophages ; Mesenchymal stem cells ; Osteogenic differentiation ; IL-23 ; Inflammation
- 刊名：Experimental Cell Research
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：339
- 期：1
- 页码：81-89
- 全文大小：7134 K
文摘
- •
Macrophages promote the osteogenic differentiation of MSCs through IL-23 secretion
- •
IL-23 binds to IL-23R in MSCs and enhances the expression of osteogenic marker genes.
- •
IL-23 activates the STAT3 and β-catenin pathway and inhibits the expression of DKK1.
- •
Macrophages contribute to excess bone formation under inflammatory conditions.