Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized two-dimensional correlation spectroscopy
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- 作者：Hao Liu ; Hongbin Gao ; Lingbo Qu ; Yanping Huang ; Bingren Xiang
- 关键词：Aromatic medicines containing nitrogen ; Structure analysis ; NIR ; 2D correlation spectrum ; Hydrogen bond ; Acetaminophen(paracetamol) ; Niacinamide ; p-Aminophenol ; Nicotinic acid
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2008
- 出版时间：15 December 2008
- 年：2008
- 卷：71
- 期：4
- 页码：1228-1233
- 全文大小：1051 K
文摘
Four aromatic medicines (acetaminophen; niacinamide; p-aminophenol; nicotinic acid) containing nitrogen were investigated by FT-NIR (Fourier transform near-infrared) spectroscopy and generalized two-dimensional (2D) correlation spectroscopy. The FT-NIR spectra were measured over a temperature range of 30–130 °C. By combining near-infrared spectroscopy, generalized 2D correlation spectroscopy and references, the molecular structures (especially the hydrogen bond related with nitrogen) were analyzed and the NIR band assignments were performed. The results will be helpful to the understanding of aromatic medicines containing nitrogen and the utility of these substances.