MicroRNA-10b suppresses goat granulosa cell proliferation by targeting brain-derived neurotropic factor
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- 作者：J.Y. Peng ; X.P. An ; F. Fang ; K.X. Gao ; H.Y. Xin ; P. Han ; L.J. Bao ; H.D. Ma ; B.Y. Cao ; caobinyun@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-10b ; Granulosa cell ; Brain-derived neurotropic factor ; Human chorionic gonadotropin
- 刊名：Domestic Animal Endocrinology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：60-67
- 全文大小：1339 K
文摘
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MiR-10b was highly expressed in monotocous goat ovaries.
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Brain-derived neurotropic factor (BDNF) was highly expressed in polytocous goat ovaries.
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Human chorionic gonadotropin induced a transient expression of BDNF in granulosa cells.
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Human chorionic gonadotropin upregulated miR-10b expression in a time-dependent manner.
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MiR-10b inhibited granulosa cell proliferation by targeting BDNF.