The oxadiazole antibacterials

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• 作者：Jeshina Janardhanan ; Mayland Chang ^{mchang@nd.edu" class="auth_mail" title="E-mail the corresponding author} ; Shahriar Mobashery ^{mobashery@nd.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Current Opinion in Microbiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：33
• 期：Complete
• 页码：13-17
• 全文大小：299 K

文摘

The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). They show in vivo efficacy in murine models of peritonitis/sepsis and neutropenic thigh MRSA infection. They are bactericidal and orally bioavailable. The oxadiazoles show promise in treatment of MRSA infection.