A one-pot laccase-catalysed synthesis of coumestan derivatives and their anticancer activity

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• 作者：Tozama Qwebani-Ogunleye^a ; Natasha I. Kolesnikova^a ; Paul Steenkamp^a ; ^b ; Charles B. de Koning^c ; Dean Brady^c ; Kevin W. Wellington^a ; ^{kwellington@csir.co.za} ; ^{kwwellington@gmail.com}
• 关键词：Laccase ; Biocatalysis ; Coumestans ; Wedelolactone analogues ; Michael addition ; Renal cancer ; Melanoma cancer ; Breast cancer ; Anticancer activity
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：25
• 期：3
• 页码：1172-1182
• 全文大小：1848 K
• 卷排序：25

文摘

A laccase, Suberase®, catalysed the synthesis of a series of coumestans at pH 7.15. Similar or better yields than other syntheses (enzymatic, chemical/electrochemical). Potent activity against melanoma UACC62 and breast MCF7 cancer cell lines.