Morphological changes in gold core-chitosan shell nanostructures at the interface with physiological media. In vitro and in vivo approach
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- 作者：C.M. Popescua ; carmen.mariana.popescu13@gmail.com" class="auth_mail" title="E-mail the corresponding author ; L. Hritcub ; D.A. Pricopa ; D. Creangaa
- 关键词：Chitosan&ndash ; AuNPs ; Brain ; Surface plasmon ; pH influence ; Neighbors interaction
- 刊名：Applied Surface Science
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：352
- 期：Complete
- 页码：103-108
- 全文大小：1729 K
文摘
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Chitosan easily adapts to pH changes reconstructing at the surface of AuNPs.
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Chitosan offeres biocompatibility to AuNPs.
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Polymeric shell allows the crossing of the blood–brain barrier.
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AuNPs do not agglomerate inside the brain and have a good dispersion within tissue.
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The polymeric coating did not degrade with pH increase.
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Interaction between AuNPs inside brain tissues is limited in strength and abundance.