Transesterification of vegetable palm oil (VPO) to biodiesel was performed over CaO-TiO2 under UV light. Effects of reaction time, VPO:methanol ratio and catalyst dosage on biodiesel yield was studied. The catalyst was reusable up to four cycles at optimized conditions with >80% biodiesel yield. The fatty methyl ester (FAME) in the biodiesel was analyzed using GC-MS. The biodiesel produced meets the ASTM D6751 specifications.