Biological response of human suture mesenchymal cells to Titania nanotube-based implants for advanced craniosynostosis therapy

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• 作者：Manpreet Bariana^a ; ^{manpreet.bariana@adelaide.edu.au} ; ^{manpreet.bariana@gmail.com} ; Prem Dwivedi^b ; Sarbin Ranjitkar^a ; John A. Kaidonis^a ; Dusan Losic^c ; ^{dusan.losic@adelaide.edu.au} ; Peter J. Anderson^a ; ^d ; ^{haemro2@hotmail.com}
• 关键词：Craniosynostosis ; Protein-releasing implants ; Titania nanotubes ; Cranial implants ; Human suture mesenchymal cells ; Cellular response
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：59-67
• 全文大小：3069 K
• 卷排序：150

文摘

TNT/Ti drug releasing implants have the potential to prevent premature suture fusion. TNTs with and without biopolymer coating were used as test implant surfaces. Suture mesenchymal cell (SMC) response was evaluated on the implants surfaces. SMC adhesion and proliferative activity decreased on test implant surfaces. Implant nanotopography and surface chemistry negatively affected SMC response.