Biomechanical insult switches PEA-15 activity to uncouple its anti-apoptotic function and promote erk mediated tissue remodeling
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- 作者：Rachel E. Exlera ; b ; c ; Xiaoxin Guoc ; Darren Chanc ; Izhar Livne-Bard ; Nevena Vicica ; b ; c ; John G. Flanaganb ; c ; d ; Jeremy M. Sivaka ; b ; c ; jsivak@uhnres.utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：PEA-15 ; ERK ; Biomechanics ; Astrocytes ; MMPs ; Apoptosis
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：340
- 期：2
- 页码：283-294
- 全文大小：2613 K
文摘
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Mechanical insult elicits a strong astrocyte response at the optic nerve head.
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In resting astrocytes PEA-15 is anti-apoptotic and inhibits ERK1/2.
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Mechanical insult induces specific PEA15 phosphorylation, blocking its activities.
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As a consequence activated ERK1/2 induces MMP2 and MMP9 secretion.
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By this mechanism PEA-15 may control injury and remodeling at the optic nerve head.