Kinetic modeling of cell metabolism for microbial production
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- 作者：Rafael S. Costa ; rafael.s.costa@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Andras Hartmann ; Susana Vinga
- 关键词：KiSAO ; kinetic simulation algorithm ontology ; MIASE ; minimum information about a simulation experiment ; MIRIAM ; minimal information required in the annotation of models ; NCBI ; National Center for Biotechnology Information ; SBO ; systems biology ontology ; SBGN-ML ; systems biology graphical notation ; SED-ML ; simulation experiment description mark-up language ; MFA ; metabolic flux analysis ; MCA ; metabolic control analysis ; CCC ; concentration control coefficient ; FCC ; flux control coefficient ; FBA ; fl
- 刊名：Journal of Biotechnology
- 出版年：2016
- 出版时间：10 February 2016
- 年：2016
- 卷：219
- 期：Complete
- 页码：126-141
- 全文大小：2044 K
文摘
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Computational kinetic models are essential for rational bioengineering applications.
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We survey the available databases, standards and software tools that can be applied for kinetic models of metabolism.
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We review and discuss modeling approaches for the construction of kinetic models for large-scale networks.
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We review some example case-studies of kinetic model-guided strain design.