Impact of juvenile idiopathic arthritis on quality of life during transition period at the era of biotherapies

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• 作者：Julien Wipff^a ; ¹ ; Laetitia Sparsa^b ; ^c ; ¹ ; ^{sparsal@ch-mulhouse.fr" class="auth_mail" title="E-mail the corresponding author} ; Anne Lohse^d ; Pierre Quartier^e ; Andre Kahan^a ; Chantal Job Deslandre^a
• 关键词：Health-related quality of life ; Juvenile idiopathic arthritis ; Transition period
• 刊名：Joint Bone Spine
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：83
• 期：1
• 页码：69-74
• 全文大小：611 K

文摘

Few studies have assessed Health-Related Quality of Life (HR-QoL) in adults following juvenile idiopathic arthritis, and none since the advent of biotherapies. The aim of our study is to assess the impact of juvenile idiopathic arthritis on quality of life in a large transitional cohort, evaluate which factors influence quality of life in juvenile idiopathic arthritis, and determine which questionnaire should be used in practice.

Methods

All consecutive juvenile idiopathic arthritis patients followed during adulthood in a transitional care program were included. Demographical, clinical and biological data were collected. The following quality of life questionnaires were administered: SF36 and EuroQoL. Age- and sex-matched controls (without rheumatic disease) were included.

Results

One hundred and sixty-one juvenile idiopathic arthritis (120 women and 41 men) and 76 (51/25) controls were included. Out of 161, sixty-five (40%) were considered to be in remission. Juvenile idiopathic arthritis had a large impact on the physical scales of quality of life. Pain seemed to be the most important factor affecting quality of life in cases of juvenile idiopathic arthritis. No significant difference was found between sub-types of juvenile idiopathic arthritis.

Conclusion

In this large transitional cohort of patients at the era of biotherapies, juvenile idiopathic arthritis has a larger effect on physical than mental scale of quality of life measures. Pain was the main factor influencing quality of life. Sub-types of juvenile idiopathic arthritis do not seem to influence quality of life.