T cell subpopulations in juvenile idiopathic arthritis and their modifications after biotherapies

详细信息    查看全文

• 作者：Laura Maggi^a ; ^b ; Lorenzo Cosmi^b ; Gabriele Simonini^c ; Francesco Annunziato^a ; ^b ; Rolando Cimaz^c ; ^{r.cimaz@meyer.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Th17 ; Nonclassic Th1 ; CD161 ; Treg cells ; Etanercept
• 刊名：Autoimmunity Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：12
• 页码：1141-1144
• 全文大小：171 K

文摘

Inflammatory T cells are thought to be central to the pathogenesis of juvenile idiopathic arthritis. In particular, recent evidence has underlined the importance of a balance between Th17 and Treg cells. Several mechanisms have come to light that control this reciprocal relationship. Moreover, it has been shown that in certain conditions, Th17 cells can shift toward a nonclassic Th1 phenotype. Anti-rheumatic biologic therapies may interfere with these mechanisms and re-establish immune tolerance.