Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78

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• 作者：Joohyun Ryu^a ; ^d ; Sung Goo Park^a ; Phil Young Lee^a ; Sayeon Cho^b ; Do Hee Lee^c ; Gwang Hoon Kim^d ; Jeong-Hoon Kim^a ; ^{jhoonkim@kribb.re.kr} ; Byoung Chul Park^a ; ^{parkbc@kribb.re.kr}
• 关键词：AGR2 ; ER stress ; UPR signaling pathway ; Dimerization
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2013
• 出版时间：11 January, 2013
• 年：2013
• 卷：430
• 期：2
• 页码：610-615
• 全文大小：444 K

文摘

Anterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers. Recently, it has been demonstrated that AGR2 is involved in the control of ER homeostasis. However, the molecular mechanism how AGR2 regulates ER stress response remains unclear. Herein we show that AGR2 homo-dimerizes through an intermolecular disulfide bond. Moreover, dimerization of AGR2 attenuates ER stress-induced cell death through the association with BiP/GRP78. Thus, these results suggest that dimerization of AGR2 is crucial in mediating the ER stress signaling pathway.