Hydroxylated biphenyls as tyrosinase inhibitor: A spectrophotometric and electrochemical study

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• 作者：Paolo Ruzza^a ; ¹ ; Pier Andrea Serra^b ; ¹ ; Davide Fabbri^c ; Maria Antonietta Dettori^c ; Gaia Rocchitta^b ; Giovanna Delogu^c ; ^{giovanna.delogu@icb.cnr.it}
• 关键词：Tyrosinase ; Spectrophotometric assay ; Biosensor ; Hydroxylated biphenyls ; Synthesis
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：1034-1038
• 全文大小：892 K
• 卷排序：126

文摘

A small collection of hydroxylated biphenyls was synthesized by straigtforward methods. Significant tyrosinase inhibitor activity was detected in most of the compounds. Selective diphenolase activity of tyrosinase enzyme have been detected by both spectrophotometric and electrochemical assays. Results of both the analytical methods were comparable.