0091: Factors associated with left atrial size in severe aortic stenosis

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• 作者：Patrick Meimoun ; ^{patrickmeimoun.md@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jerome Clerc ; Sonia Martis ; Frederic Elmkies ; Anne Luycx-Bore ; Hamdane Zemir ; Jean-Philippe Detienne ; Jacques Boulanger
• 刊名：Archives of Cardiovascular Diseases Supplements
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：8
• 期：1
• 页码：48-49
• 全文大小：67 K

文摘

Left atrial (LA) enlargement is associated with a poorer prognosis in several diseases, including aortic stenosis (AS). However, apart diastolic dysfunction, the main determinants of LA size in the setting of aortic stenosis are poorly understood.

Objective

to assess the factors correlated with LA size in patients with severe AS (aortic valve area (AVA) <1cm² or <0.6cm²/m²) with preserved left ventricular ejection fraction (LVEF >50%).

Methods

80 consecutive patients with isolated severe AS in sinus rhythm (mean age 72±10 years, AVA 0.8±0.2cm ², 0.44±0.1cm ²/m², mean gradient 45±15mmHg, LVEF 68±10%) underwent a comprehensive transthoracic Doppler echocardiography including the measurement of the LA volume at end-systole by the biplane area-length method (from the 4-and 2-apical chamber views), indexed to body surface area (ml/m²), LVEF by the biplane Simpson’s method, LV mas by the ASE M-mode method, and early (e’), late diastolic (a’), and systolic (Sa) mitral annular Doppler tissue velocities were calculated as an average of the septal and lateral values.

Results

The mean LA volume was 33±12mL/m ² (extreme values: 13 and 72mL/m²), and dilated LA (defined as LA ≥34ml/m²) was found in 34 cases (43%). In univariate analysis, indexed LA volume was significantly linked to age, hypertension (all, p<0.05), LV mass/m² (r=0.5), pulmonary artery systolic pressure (PASP) (r=0.55), mitral E/A ratio (r=0.32), E/e’ ratio (r=0.46), a’ (r=–0.4), LVEF (r=–0.3) (all, p<0.01), and Sa (r=–0.27, p<0.05). In multivariate analysis, indexed LA volume was independently associated with LV mass/m², E/e’, and PASP (all, p<0.01). Furthermore indexed LA volume was significantly higher in symptomatic patients (n=46) when compared to asymptomatic patients (36±13 vs. 28±10mL/m ², p<0.01), with an independent link in a separate multivariate analysis (p<0.01), and was independently correlated to NT-proBNP (Log) in a subgroup of 53 patients who had plasmatic values of this biomarker available (r=0.6, p<0.01).

Conclusion

in severe AS with preserved LVEF, LA size is higher in symptomatic patients, and is independently linked to LV remodeling, LV diastolic dysfunction, and PASP, as well as to NT-proBNP a surrogate of increased LV wall stress.