Diffuse fibrosis leads to a decrease in unipolar voltage: Validation in a swine model of premature ventricular contraction-induced cardiomyopathy

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• 作者：Yasuaki Tanaka ; MD ; Dolkun Rahmutula ; MD ; PhD ; Srikant Duggirala ; MD ; Babak Nazer ; MD ; Qizhi Fang ; MD ; Jeffrey Olgin ; MD ; Richard Sievers ; BS ; Edward P. Gerstenfeld ; MS ; MD ; FHRS ; ^{egerstenfeld@medicine.ucsf.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cDNA ; complementary DNA ; EF ; ejection fraction ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; LV ; left ventricle/ventricular ; LVEDD ; left ventricular end-diastolic diameter ; mRNA ; messenger RNA ; PVC ; premature ventricular contraction ; RV ; right ventricular
• 刊名：Heart Rhythm
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：13
• 期：2
• 页码：547-554
• 全文大小：3646 K

文摘

Frequent premature ventricular contractions (PVCs) may lead to dilated cardiomyopathy. A leftward shift in the unipolar voltage distribution in patients with cardiomyopathy has also been described and attributed to increased fibrosis.

Objectives

We established a swine model of PVC-induced cardiomyopathy and assessed (1) whether an increase in left ventricular fibrosis occurs and (2) whether increased fibrosis leads to a leftward shift in the unipolar voltage distribution.

Methods

Ten swine underwent implantation of ventricular pacemakers; 6 programmed to deliver a 50% PVC burden and 4 controls without pacing. Voltage maps were acquired at baseline and after 14 weeks of ventricular bigeminy.

Results

In the PVC group, left ventricular ejection fraction decreased from 67% ± 7% to 44% ± 15% (P < .05) with no change in controls (71% ± 6% to 73% ± 4%; P = .56). The fifth percentile of the bipolar and unipolar voltage distribution at baseline was 1.63 and 5.36 mV, respectively. In the control group, after 14 weeks of pacing there was no significant change in % bipolar voltage <1.5 mV (pre 1.2% vs post 2.2%; P = .34) or % unipolar voltage <5.5 mV (pre 4.0% vs post 3.5%; P = .20). In the PVC group, there was a significant increase in % unipolar voltage <5.5 mV (5.4% vs 12.6%; P < .01), with a leftward shift in the unipolar voltage distribution. Histologically, % fibrosis was increased in the PVC group (control 1.8% ± 1.3% vs PVC 3.4% ± 2.6%; P < .01).

Conclusion

PVC-induced cardiomyopathy in swine leads to an increase in interstitial fibrosis and a leftward shift in the unipolar voltage distribution. These findings are consistent with findings in humans with PVC-induced cardiomyopathy.