Mechanisms of Centrosome Separation and Bipolar Spindle Assembly

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• 作者：Marvin E. Tanenbaum ; René ; H. Medema
• 刊名：Developmental Cell
• 出版年：2010
• 出版时间：14 December 2010
• 年：2010
• 卷：19
• 期：6
• 页码：797-806
• 全文大小：568 K

文摘

Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly.