Fragmentary myoclonus in sleep revisited: A polysomnographic study in 62 patients

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• 作者：Birgit Frauscher^a ; ¹ ; Alexander Kunz^a ; ¹ ; Elisabeth Brandauer^a ; Hanno Ulmer^b ; Werner Poewe^a ; Birgit H&#xf6 ; gl^a ; ^{birgit.ho@i-med.ac.at}
• 关键词：Normal variant ; Sleep ; Wakefulness ; Jerk ; EMG potential ; ICSD ; Movement disorder ; Periodic leg movements
• 刊名：Sleep Medicine
• 出版年：2011
• 出版时间：April 2011
• 年：2011
• 卷：12
• 期：4
• 页码：410-415
• 全文大小：523 K

文摘

ass=""h4"">Study objectives

To investigate the frequency of fragmentary myoclonus (FM) in a sleep-disorder population, to analyze its distribution across sleep stages and to examine potential associations with clinical correlates and night-to-night variability.

ass=""h4"">Design

Retrospective review of 102 polysomnographic records.

ass=""h4"">Setting

Sleep laboratory at a University Hospital Neurology Department.

ass=""h4"">Patients

Sixty-two sleep-disorder patients.

ass=""h4"">Interventions

None.

ass=""h4"">Measurements and results

Fragmentary myoclonus (FM) was counted according to published criteria. Sleep stage specific FM indices (FMI) were calculated for each patient. Median FMI was 39.5/h sleep. FMI was the highest in REM sleep, followed by similar indices in wakefulness, S1 and S2 sleep, and was the lowest in S3/S4 sleep (n.s.). FMI increased with age (ρ&#xa0;=&#xa0;0.350, P&#xa0;=&#xa0;0.005). Men had a higher FMI than women (median 55.8/h vs. 24.1/h, P&#xa0;=&#xa0;0.042). In addition, FMI was positively correlated with the presence of sleep-related breathing disorders (ρ&#xa0;=&#xa0;0.270, P&#xa0;=&#xa0;0.036), respiratory indices (apnea–hypopnea index: ρ&#xa0;=&#xa0;0.403, P&#xa0;=&#xa0;0.002; oxygen desaturation index: ρ&#xa0;=&#xa0;0.378, P&#xa0;=&#xa0;0.004) and body mass index (ρ&#xa0;=&#xa0;0.28, P&#xa0;=&#xa0;0.028). In a linear regression model, age, male sex and oxygen desaturation index were significant (P&#xa0;<&#xa0;0.05). FMI night-to-night variability was 1.6 (range: 1.0–3.9).

ass=""h4"">Conclusion

Fragmentary myoclonus was present in every patient of this sleep-disorder population. Its clinical significance is unknown, but the association with oxygen desaturation index points to an association with sleep-related breathing disorders. Since FMI was similar during wakefulness and light sleep, these data challenge the concept of a primarily sleep-related phenomenon.