Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity
详细信息 查看全文
- 作者：Vanja Sisirak1 ; 12 ; Benjamin Sally1 ; 2 ; 12 ; Vivette D&rsquo ; Agati3 ; Wilnelly Martinez-Ortiz4 ; Z. Birsin Ö ; zç ; akar5 ; Joseph David1 ; Ali Rashidfarrokhi1 ; Ada Yeste6 ; Casandra Panea2 ; Asiya Seema Chida7 ; Milena Bogunovic8 ; Ivaylo I. Ivanov2 ; Francisco J. Quintana6 ; Inaki Sanz7 ; Keith B. Elkon9 ; Mustafa Tekin10 ; Fatoş Yalç ; ınkaya5 ; Timothy J. Cardozo4 ; Robert M. Clancy11 ; Jill P. Buyon11 ; Boris Reizis1 ; 2 ; 11 ; boris.reizis@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：166
- 期：1
- 页码：88-101
- 全文大小：3238 K
文摘
- •
Rapid anti-DNA antibody response, followed by SLE in Dnase1l3-deficient mice
- •
Autoreactivity is repressed by circulating DNASE1L3 and is independent of STING
- •
DNASE1L3 digests genomic DNA in microparticles released from apoptotic cells
- •
DNASE1L3 prevents autoantibody binding to chromatin on microparticle surface