Mixed-ligand copper(I) halide complexes bearing 4,5-bis(diphenylphosphano)-9,9-dimethyl-xanthene and N-methylbenzothiazole-2-thione: Synthesis, structures, luminescence and antibacterial activity mediated by DNA and membrane damage

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• 作者：O. Evangelinou^a ; A.G. Hatzidimitriou^a ; E. Velali^b ; A.A. Pantazaki^b ; ^{natasa@chem.auth.gr" class="auth_mail} ; N. Voulgarakis^c ; P. Aslanidis^a ; ^{aslanidi@chem.auth.gr" class="auth_mail}
• 关键词：Copper(I) ; N-Methylbenzothiazole-2-thione ; Luminescence ; Crystal structures ; Antimicrobial activity ; DNA interaction ; Reactive oxygen species (ROS)
• 刊名：Polyhedron
• 出版年：18 April, 2014
• 年：2014
• 卷：72
• 期：Complete
• 页码：122-129
• 全文大小：1124 K

文摘

The 1:1 M-ratio reaction between copper(I) bromide or iodide and 4,5-bis(diphenylphosphano)-9,9-dimethyl-xanthene (xantphos) in acetonitrile results in the formation of [CuX(xantphos)] (X = Br, I), which further reacts with N-methylbenzothiazole-2-thione (mbtt) to afford the mononuclear mixed-ligand complexes [CuX(xantphos)(mbtt)]. The molecular structures of the complexes, established by single-crystal X-ray diffraction, feature a distorted tetrahedral geometry around the metal center, with the diphosphane acting as a chelate. The new compounds are strongly emissive in the solid state at room temperature. The complexes were also screened for antibacterial activity and their ability to interact with CT-DNA in vitro and to produce reactive oxygen species (ROS).