Anticancer activity of synthetic bis(indolyl)methane-ortho-biaryls against human cervical cancer (HeLa) cells
详细信息 查看全文
- 作者：Vellekkatt Jamsheenaa ; c ; 1 ; Ganesan Shilpaa ; b ; 1 ; Jayaram Saranyab ; Nissy Ann Harryb ; Ravi Shankar Lankalapallia ; c ; ravishankar@niist.res.in" class="auth_mail" title="E-mail the corresponding author ; Sulochana Priyaa ; b ; priyasulu@niist.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bis(indolyl)methane ; Biaryl ; HeLa cells ; H9C2 cells ; Apoptosis ; Matrix metalloproteinases
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：247
- 期：Complete
- 页码：11-21
- 全文大小：3086 K
文摘
- •
12 novel ortho biaryl BIMs (compounds 1–12) were synthesized.
- •
Compounds 1, 4 and 11 induced caspase mediated apoptosis in HeLa cells.
- •
They were nontoxic to normal H9C2 cells.
- •
These three compounds decreased the mitochondrial membrane potential in HeLa cells.
- •
They decreased cellular migration and production of MMP-2 and MMP-9 in HeLa cells.