Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes

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• 作者：Santhisudha Sarva^a ; Jayaprakash Soora Harinath^a ; Siva Prasad Sthanikam^a ; Selvarajan Ethiraj^b ; Mohanasrinivasan Vaithiyalingam^b ; Suresh Reddy Cirandur^a ; ^{csrsvu@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Bis(indolyl)methanes ; Microwave irradiation ; Antibacterial activity ; Anti-inflammatory activity
• 刊名：Chinese Chemical Letters
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：27
• 期：1
• 页码：16-20
• 全文大小：729 K

文摘

A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac, respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity. Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound.