Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)
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- 作者：Sandrine Skiba-Cassy ; skiba@st-pee.inra.fr" class="auth_mail" title="E-mail the corresponding author ; Inge Geurden ; Sté ; phane Panserat ; Iban Seiliez
- 关键词：ACLY ; ATP citrate lyase ; ATF4 ; activating transcription factor 4 ; ASNS ; asparagine synthetase ; CAT1 ; cationic amino acid transporter 1 ; CPT1 ; carnitine palmitoyltransferase 1 ; eIF2α ; elongation initiation factor 2α ; FAS ; fatty acid synthesis ; FBPase ; fructose-1 ; 6-bisphosphatase ; GCN2 ; general control non-derepressible 2 ; GDH ; glutamate dehydrogenase ; G6Pase ; glucose-6-phosphatase ; HOAD ; hydroxyacyl-CoA dehydrogenase ; mTOR ; mechanistic target of rapamycin ; PEPCK ; phosphoé ; nolpyruvate carbox
- 刊名：Aquaculture
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：454
- 期：Complete
- 页码：56-65
- 全文大小：992 K
文摘
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Dietary methionine deficiency and excess differently affect hepatic gene expression.
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Methionine acts as a signaling molecule regulating not only growth but also metabolism.
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Finely adjust methionine supplementation to fish requirement is essential to avoid potential metabolic side effects.