5">Enzymes involved in acetate production in Entamoeba histolytica were studied.
In axenic amoebae acetate is produced only by acetyl-CoA synthetase (ACS).
5">ACS does not significantly contribute to ATP production in the parasite.
ACS is responsible for CoA regeneration under oxidative stress conditions.
5">PPi-acetate kinase appears to have a marginal contribution to PPi supply.