Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study

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• 作者：Robert Bissonnette ; MD^a ; ^{rbissonnette@innovaderm.ca} ; Yves Poulin ; MD^b ; Janice Drew ; MPH^c ; Hans Hofland ; PhD^c ; Jerry Tan ; MD^d
• 关键词：acetyl-coenzyme A carboxylase inhibitor ; acne vulgaris ; inflammatory lesions ; investigator global assessment ; local skin reactions ; noninflammatory lesions ; olumacostat glasaretil
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：76
• 期：1
• 页码：33-39
• 全文大小：861 K
• 卷排序：76

文摘

Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears.ObjectivesSafety and efficacy of OG 7.5% gel were evaluated in patients with moderate to severe facial acne vulgaris.MethodsPatients were randomized (1:1) to twice-daily application of OG or vehicle for 12 weeks. Efficacy was measured through changes in lesion counts and improvement in acne severity scores.ResultsA total of 108 patients received OG (n = 53) or vehicle (n = 55); these groups had mean baseline counts of 29.7 and 28.6 inflammatory and 40.9 and 38.8 noninflammatory lesions, respectively. At week 12, OG treatment showed greater reductions from baseline in inflammatory lesions (−63.9% vs −45.9%; P = .0006) and noninflammatory lesions (−48.1% vs −28.8%; P = .0025), and more patients with greater than or equal to 2-grade improvement in investigator global assessment score (24.5% vs 7.3%; P = .0070) than vehicle. Application-site adverse events (typically mild or moderate intensity) were more common with OG.LimitationsLarger trials are needed to optimize OG dosing and confirm the current results.ConclusionOG was well tolerated and showed evidence of efficacy, suggesting further development is warranted.