Abnormally increased surface expression of AMPA receptors in the cerebellum, cortex and striatum of Cln3鈭?鈭?/sup> mice
详细信息 查看全文
- 作者：Attila D. Ková ; csa ; Caitlin Hofa ; David A. Pearcea ; b ; David.Pearce@sanfordhealth.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; 伪-amino-3-hydroxy-5-methyl-4-isoxazolepropionate ; NMDA ; N-methyl-d-aspartate ; BS3 ; bis[sulfosuccinimidyl] suberate ; ACSF ; artificial cerebrospinal fluid
- 刊名：Neuroscience Letters
- 出版年：2015
- 出版时间：21 October 2015
- 年：2015
- 卷：607
- 期：Complete
- 页码：29-34
- 全文大小：1329 K
文摘
- •
We examined AMPA receptor surface expression in a mouse model of CLN3 disease.
- •
Surface levels of GluA1 and GluA2 were elevated in the cerebellum of Cln3−/− mice.
- •
Surface level of GluA2 was elevated in the cortex and striatum of Cln3−/− mice.
- •
These data suggest that CLN3 is involved in AMPA receptor cycling.