GluN2B-containing NMDA receptors contribute to the beneficial effects of hydrogen sulfide on cognitive and synaptic plasticity deficits in APP/PS1 transgenic mice
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- 作者：Yuan-Jian Yanga ; b ; &dagger ; ; Ying Zhaoc ; &dagger ; ; Bin Yub ; &dagger ; ; Guo-Gang Xud ; Wei Wange ; Jin-Qiong Zhanb ; Zhen-Yu Tange ; Ting Wangf ; tingting0301@126.com" class="auth_mail" title="E-mail the corresponding author ; Bo Weia ; jxmh_wb@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aβ ; beta-amyloid ; ACSF ; artificial cerebrospinal fluid ; AD ; Alzheimer&rsquo ; s disease ; ANOVA ; analysis of variance ; APP ; amyloid precursor protein ; BDNF ; brain derived neurotrophic factor ; BS3 ; bis(sulfosuccinimidyl)suberate ; CaMKII ; calcium/calmodulin-activated kinase II ; CNQX ; 6-cyano-7-nitroquinoxaline-2 ; 3-dione ; CREB ; cAMP-response element binding protein ; EPSPs ; excitatory postsynaptic potentials ; H2S ; hydrogen sulfide ; LTP ; long-term potentiation ; NaHS ; sodium hydrosulfide ; NMDARs ; N-methy
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：29 October 2016
- 年：2016
- 卷：335
- 期：Complete
- 页码：170-183
- 全文大小：2028 K
文摘
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Elevating hippocampal H2S ameliorates cognitive deficits in APP/PS1 mice.
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H2S elevation restores hippocampal NMDAR-dependent LTP in APP/PS1 mice.
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Elevation of H2S restores synaptic GluN2B expression and response in APP/PS1 mice.
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Elevation of H2S enhances NMDAR-dependent signaling in APP/PS1 mice.
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Blockade of GluN2B abolishes the beneficial effects of H2S elevation in APP/PS1 mice.