Synthesis of novel imidazo[1,2-a]pyridine-4-hydroxy-2H-coumarins by Groebke-Blackburn-Bienaymé multicomponent reaction as potential NS5B inhibitors

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• 作者：Parth Manvar ; Faraz Shaikh ; Rajesh Kakadiya ; ^{r.kakadiya.82@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Krunal Mehariya ; Ranjan Khunt ; Bipin Pandey ; Anamik Shah ; ^{anamik_shah@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Groebke&ndash ; Blackburn&ndash ; Bienaymé ; reaction ; Hepatitis C virus ; 4-Hydroxy-3-Formylcoumarin ; Imidazo[1 ; 2-a]pyridine ; NS5B inhibitors ; Molecular docking ; Multicomponent reaction (MCR)
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：10 March 2016
• 年：2016
• 卷：72
• 期：10
• 页码：1293-1300
• 全文大小：1205 K

文摘

A new series of imidazo[1,2m>-am>]pyridine-coumarin hybrid has been developed by combining two biologically active pharmacophores coumarin and imidazo[1,2m>-am>]pyridine following a Groebke–Blackburn–Bienaymé multicomponent reaction (MCR). Molecular docking studies of these novel compounds with nonstructural protein 5B (NS5B) exhibited promising binding interactions by forming hydrogen bond at Ser476, Trp528, Arg422 and Arg501, directly and hydrophobic contacts with Leu419, Ile482, Leu497, Leu489, Met423, Leu474 and His475, which are potentially useful for a new scaffold discovery.