Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ
详细信息 查看全文
- 作者：Zhifeng Huang1 ; 2 ; William M. Marsiglia3 ; Upal Basu Roy4 ; Nader Rahimi5 ; Dariush Ilghari2 ; Huiyan Wang1 ; 2 ; Huaibin Chen1 ; 2 ; Weiming Gai2 ; Steven Blais6 ; Thomas A. Neubert6 ; Alka Mansukhani4 ; Nathaniel J. Traaseth3 ; Xiaokun Li1 ; xiaokunli@wzmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Moosa Mohammadi2 ; moosa.mohammadi@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 January 2016
- 年：2016
- 卷：61
- 期：1
- 页码：98-110
- 全文大小：3950 K
文摘
- m" id="list_ulist0010">
- •
cSH2 of PLCγ mediates the recruitment and phosphorylation of PLCγ by RTKs
- •
Phosphorylation of PLCγ requires the formation of a 2:1 FGFR-PLCγ complex
- •
One FGFR monomer recruits PLCγ delivering it for phosphorylation by the other FGFR
- •
cSH2 undergoes a conformational change upon recruitment to the phosphorylated FGFR