Bioinspired, biomimetic, double-enzymatic mineralization of hydrogels for bone regeneration with calcium carbonate

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• 作者：Marco A. Lopez-Heredia^a ; Agata Łapa^b ; Ana C. Mendes^c ; Lieve Balcaen^d ; Sangram Keshari Samal^e ; ^f ; Feng Chai^a ; Pascal Van der Voort^g ; Christian V. Stevens^h ; Bogdan V. Parakhonskiyⁱ ; ^j ; Ioannis S. Chronakis^c ; Frank Vanhaecke^d ; Nicolas Blanchemain^a ; Elżbieta Pamuła^b ; Andre G. Skirtach^f ; ⁱ ; Timothy E.L. Douglasⁱ ; ^{Timothy.Douglas@UGent.be}
• 关键词：Biomaterials ; Biomimetic ; Composite materials ; Sol-gel preparation
• 刊名：Materials Letters
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：190
• 期：Complete
• 页码：13-16
• 全文大小：1402 K
• 卷排序：190

文摘

Gellan Gum (GG) hydrogels were mineralized with CaCO3 by enzyme urease (U) Combined action of U and second enzyme carbonic anhydrase (CA) promoted mineralization. CaCO3 formed is calcite. Osteoblast-like cells grow on GG hydrogels mineralized with CaCO3.