Left ventricular hypertrophy in hypertensive type 2 diabetic patients according to renal function

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• 作者：A. Blanchet Deverly ; P. Kangambega ; K. Hue ; J.-P. Donnet ; H. Merault ; L. Foucan
• 关键词：Echocardiography ; Dialysis ; Type 2 diabetes mellitus ; Hypertension ; Pulse pressure
• 刊名：Diabetes Metabolism
• 出版年：2009
• 出版时间：September 2009
• 年：2009
• 卷：35
• 期：4
• 页码：280-286
• 全文大小：241 K

文摘

Aim

Cardiovascular disease is the main cause of death in diabetic patients undergoing haemodialysis. Dialysis and hypertension increase left ventricular hypertrophy (LVH), a strong predictor of cardiovascular events. This study evaluated left ventricular structure and function in three groups of hypertensive type 2 diabetic patients with different renal function, and assessed the factors associated with LVH, in an Afro-Caribbean population.

Methods

Left ventricular structure and function were measured by ultrasonography. Group 1 consisted of 150 patients with normal renal function, group 2 included 183 patients with renal dysfunction and the third group comprised 75 dialysis patients.

Results

Left ventricular mass/height^2.7 increased from group 1 to groups 2 and 3 (49.00 g/m^2.7, 57.12 g/m^2.7 and 59.75 g/m^2.7, respectively; P < 0.0001). The prevalences of LVH were 48.3 % in group 1, 64.8 % in group 2 and 70.3 % in the dialysis patients (P = 0.001). LVH was more concentric than eccentric in groups 2 and 3.

The factors significantly associated with LVH were obesity in groups 1 and 2, and an increase of 10 mmHg in pulse pressure in groups 2 and 3, according to multivariate logistic-regression analysis.

Conclusion

Our study confirmed that, in a population of Afro-Caribbean hypertensive type 2 diabetic patients, renal failure was associated to an increased left ventricular mass/height^2.7. The data show that the variables associated with LVH differ according to renal profile. This finding will be of value in the treatment and follow-up of these patients.