Ex vivo efficacy of gemifloxacin in experimental keratitis induced by methicillin-resistant Staphylococcus aureus
详细信息 查看全文
- 作者：Andreana Marino ; anmarino@unime.it" class="auth_mail" title="E-mail the corresponding author ; Anna Rita Blanco ; Giovanna Ginestra ; Antonia Nostro ; Giuseppe Bisignano
- 关键词：Antibiotic resistance ; Methicillin-resistant Staphylococcus aureus ; Gemifloxacin ; In vitro antibacterial activity ; Ex vivo keratitis model ; Dose&ndash ; response effect
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：48
- 期：4
- 页码：395-400
- 全文大小：456 K
文摘
- •
Ex vivo efficacy of 0.3% gemifloxacin (GFX) against MRSA-induced keratitis was evaluated.
- •
GFX was the most efficient fluoroquinolone assayed in vitro.
- •
Ex vivo results predicted that GFX may be an effective topical therapy.
- •
Dose–response efficacy showed good performance at lower concentrations.
- •
The ex vivo model has been enabled to mimic in vivo bacterial infection.