A straightforward synthesis and structure of unprecedented iminium salts of dihydropyrido[3,2-e][1,3]thiazines

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• 作者：Margarita Suá ; rez ; Hector Novoa ; Yamila Verdecia ; Estael Ochoa ; Amaury Alvarez ; Rolando Pé ; rez ; Roberto Martí ; nez-Alvarez ; Dolores Molero ; Carlos Seoane ; Norbert M. Blaton et al.
• 关键词：2-Imino pyrido[ ; 3 ; 2-e] ; [ ; 1 ; 3] ; thiazines ; X-ray analysis ; 1 ; 4-Dihydropyridines ; Iminium salts
• 刊名：Tetrahedron
• 出版年：2006
• 出版时间：13 February 2006
• 年：2006
• 卷：62
• 期：7
• 页码：1365-1371
• 全文大小：194 K

文摘

Unprecedented 2-iminium chloride salts of 5,8-dihydro-2H-pyrido[3,2-e][1,3]thiazines derivatives (8) were easily synthesized in one step from the corresponding o-chloroformyl-1,4-dihydropyridine (2) and thiourea. The structural study has been carried out by X-ray crystallography and theoretical calculations at the B3LYP/6-31G* levels and reveal that the new salts exhibit appropriate structural features to behave as calcium channel modulators.