PKC-θ function at the immunological synapse: prospects for therapeutic targeting

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• 作者：Alexandra Zanin-Zhorov¹ ; Michael L. Dustin¹ ; ^* ; Bruce R. Blazar² ; ^{blaza001@umn.edu"" rel=""nofollow}
• 刊名：Trends in Immunology
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：32
• 期：8
• 页码：358-363
• 全文大小：336 K

文摘

Protein kinase C (PKC)-θ regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-θ in T cells is complex. PKC-θ plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-θ is required for the development of natural CD4⁺Foxp3⁺ regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-θ in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-θ in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.