The functions of estrogen receptor beta in the female brain: A systematic review
详细信息 查看全文
- 作者：Kris G. Vargas<sup>asup> ; Jelena Milic<sup>asup> ; Asija Zaciragic<sup>asup> ; Ke-xin Wen<sup>asup> ; Loes Jaspers<sup>asup> ; Jana Nano<sup>asup> ; Klodian Dhana<sup>asup> ; Wichor M. Bramer<sup>bsup> ; Bledar Kraja<sup>asup><sup> ; sup><sup>csup><sup> ; sup><sup>dsup> ; Ed van Beeck<sup>esup> ; M. Arfan Ikram<sup>asup><sup> ; sup><sup>fsup><sup> ; sup><sup>gsup> ; Taulant Muka<sup>asup><sup> ; sup><sup>t.muka@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding authorsup><sup> ; sup><sup>taulantmuka@yahoo.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Oscar H. Franco<sup>asup>
- 关键词：Estrogen receptor beta ; Neurological disorders ; Psychiatry ; Brain ; Menopause ; Systematic review
- 刊名：Maturitas
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：41-57
- 全文大小：1320 K
文摘
- ss="listitem" id="list_lis0025">
- ss="label">•
Forty-nine animal studies investigating the functions of estrogen receptor beta in the female brain were included in this review.
- ss="label">•
Estrogen receptor beta regulated protein expression of genes involved in neurological functions and promoted neurogenesis.
- ss="label">•
Estrogen receptor beta modulated the neuroendocrine regulation of stress response and reduced anxiety- and depression-like behaviors.
- ss="label">•
The estrogen receptor beta agonist diarylpropionitrile may induce a significant reduction of hippocampal ApoE mRNA and protein expression.
- ss="label">•
Therapies targeting estrogen receptor beta could constitute a novel preventive strategy and treatment for neurological diseases in females.