Early and delayed complications of polypectomy in a community setting: The SPoC prospective multicentre trial

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• 作者：Arnaldo Amato^a ; ^{arnamato@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Franco Radaelli^a ; Marco Dinelli^b ; Cristiano Crosta^c ; Gianpaolo Cengia^d ; Paolo Beretta^e ; Massimo Devani^f ; Davide Lochis^g ; Giampiero Manes^h ; Lucia Finiⁱ ; Silvia Paggi^a ; Giovanni Rubis Passoni^j ; Alessandro Repici^k
• 关键词：Colonoscopic polypectomy ; Polypectomy complications
• 刊名：Digestive and Liver Disease
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：48
• 期：1
• 页码：43-48
• 全文大小：253 K

文摘

Colonoscopic polypectomy is effective in reducing the incidence of and mortality from colorectal cancer, but is not complication-free.

Aims

To evaluate the incidence of early and delayed polypectomy complications and factors associated with their occurrence in a community setting.

Methods

Web-database collection of patients’ and polyp's features in consecutive colonic polypectomies during a 3-month period in 18 endoscopy centres.

Results

Data on 5178 polypectomies in 2692 patients (54.3% males, mean age 59 years) were collected. The majority of the polyps were <10 mm (83.5%). Antithrombotic agents were taken by 22.7% of patients, 57.3% of which withheld them before the procedure. Overall, 5 patients experienced perforations (0.2%) and 114 had bleeding (4.2%); the overall complication rate was 4.4%. Early complications were observed in 87 (3.2%); delayed complications (all major bleedings) occurred in 32 (1.2%). At multivariate analysis polyp size (size >10 mm: OR 4.35, 95% CI 5.53–7.48) and, inversely, right-sided location (OR 0.58, 95% CI 0.36–0.94) were correlated with bleeding events. The use of antithrombotics was associated with 5-fold increased risk of delayed bleeding.

Conclusions

In the community setting, polypectomy was associated with a 1.4% risk of major complications. Polyp size and, inversely, right-sided location were associated with early bleeding; the use of antithrombotics increased the risk of delayed events.