Acute and delayed bleeding requiring embolization after image-guided liver biopsy in patients with cancer

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• 作者：Alan A. Sag^a ; ^b ; ^{asag@ku.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Lynn A. Brody^a ; Majid Maybody^a ; Joseph P. Erinjeri^a ; Xiaodong Wang^a ; ^c ; Thomas Wimmer^a ; ^d ; Mikhail Silk^a ; Elena N. Petre^a ; Stephen B. Solomon^a
• 关键词：Image-guided biopsy ; Hemorrhage ; Embolization ; Therapeutic ; Radiology ; Interventional
• 刊名：Clinical Imaging
• 出版年：2016
• 出版时间：May-June 2016
• 年：2016
• 卷：40
• 期：3
• 页码：535-540
• 全文大小：680 K

文摘

To report incidence of acute versus delayed presentations of bleeding requiring embolization after focal liver biopsy, in correlation with angiographic findings and treatment success rates. The available literature will be reviewed as well.

Materials and methods

Health Insurance Portability and Accountability Act-compliant institutional review board approved retrospective review of 2180 consecutive patients undergoing 2335 targeted liver biopsies at a tertiary-care cancer center. Hepatic arterial embolization episodes within 30 days from biopsy were identified via radiology PACS. Electronic medical record review was performed for indication of embolization and postembolization clinical course.

Results

The incidence of postbiopsy bleeding requiring embolization was 0.5% (12/2335 biopsies). In those with bleeding, 1/12 (8%) had no hepatic arterial findings at angiography. Angiographic hepatic arterial findings resolved after embolization in 11/11 patients (100% technical success). Bleeding ceased after embolization in 10/12 patients (83% clinical success). Complications were seen in 2/12 (17%) patients: cholecystitis and hepatic infarct, respectively. Delayed presentation of bleeding (defined as > 24 h postbiopsy) occurred in 5/12 (42%) patients; the longest latency was 12 days.

Conclusion

The overall incidence of bleeding requiring embolization in our population was 0.5%. This complication rate compares favorably to the 0–4.2% (median: 0.29%) rate quoted in the available, heterogeneous, literature on this topic. Delayed presentation occurred in almost half of patients. Arterial embolization carries excellent technical and clinical success rates.