Long-Acting Anticoagulant Rodenticide (Superwarfarin) Poisoning: A Review of Its Historical Development, Epidemiology, and Clinical Management
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- 作者：Nathan Kinga ; ncking@uci.edu" class="auth_mail" title="E-mail the corresponding author ; Minh-Ha Tranb ; 1 ; minhhat1@uci.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PT ; prothrombin time ; INR ; international normalized ratio ; PTT ; partial thromboplastin time ; LAAR ; long-acting anticoagulant rodenticide ; PCC ; prothrombin complex concentrate ; VKA ; vitamin K antagonist ; VKOR ; vitamin K epoxide reductase
- 刊名：Transfusion Medicine Reviews
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：29
- 期：4
- 页码：250-258
- 全文大小：484 K
文摘
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From 1987 to 2012, 315 951 human exposures to LAARs were reported.
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Hemorrhagic symptoms often required IV vitamin K1 in excess of 50 to 100 mg.
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Coagulopathy treatment courses ranged from 28 to 730 days with an average of 168 days.
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Most commonly reported symptoms were hematuria, gingival bleeding, and epistaxis.
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In adults, LAAR poisoning may be obscure when associated with surreptitious abuse.