Hormonal regulation of platypus Beta-lactoglobulin and monotreme lactation protein genes

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• 作者：Ashwantha Kumar Enjapoori^a ; ^{ashwantha.enjapoori@deakin.edu.au} ; Christophe M. Lefè ; vre^a ; ^{christophe.lefevre@deakin.edu.au} ; Kevin R. Nicholas^a ; ^b ; ^{kevin.nicholas@deakin.edu.au} ; Julie A. Sharp^a ; ^b ; ^c ; ^{julie.sharp@deakin.edu.au}
• 关键词：Platypus ; Echidna ; Hormonal regulation ; Milk protein gene expression ; Monotreme lactation protein ; Platypus Beta-lactoglobulin gene
• 刊名：General and Comparative Endocrinology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：242
• 期：Complete
• 页码：38-48
• 全文大小：2997 K
• 卷排序：242

文摘

Prolactin, glucocorticoid and insulin signalling regulates platypus MLP and BLG milk protein gene expression in BME-UV1 cells. Transcription factors essential for the hormonal responsiveness are conserved in MLP and BLG promoters. Monotreme milk protein genes are hormonally regulated in the same way as distantly related marsupial and eutherian mammals. Lactogenic hormonal regulation of milk protein gene expression evolved at least 166 million years ago.