Retinal Pigment Epithelial Tear Following Intravitreal Pegaptanib Sodium

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• 作者：Mandeep Singh Dhalla ; Kevin J. Blinder ; Asheesh Tewari ; Seenu M. Hariprasad and Rajendra S. Apte
• 刊名：American Journal of Ophthalmology
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：141
• 期：4
• 页码：752-754
• 全文大小：222 K

文摘

Purpose

To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium. To our knowledge, this is the first report of this finding after intraocular antivascular endothelial growth factor therapy.

Design

Observational case reports.

Methods

Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of age-related macular degeneration. Both patients were treated with an intravitreal injection of pegaptanib sodium.

Results

One patient developed a retinal pigment epithelium tear one week after the intravitreal injection. The second patient developed a retinal pigment epithelium tear eight weeks after treatment.

Conclusions

Although these cases may represent natural history, there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib sodium. Further studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatment with antivascular endothelial growth factor agents.